Kruppel-Like Factors and Vascular Inflammation: Implications for Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Interplay Between NF-jB and Kruppel-like Factors in Vascular Inflammation and Atherosclerosis: Location, Location, Location
A therosclerosis is a highly complex process involving the dynamic interplay between cell types intrinsic (eg, endothelial cells [ECs] and smooth muscle cells [SMCs]) and extrinsic (eg, lymphocytes and myeloid cells) to the blood vessel wall. Over the last several decades extensive work has been conducted that details the many molecular pathways involved in mediating the pathologic vascular inf...
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A therosclerosis is a highly complex process involving the dynamic interplay between cell types intrinsic (eg, endothelial cells [ECs] and smooth muscle cells [SMCs]) and extrinsic (eg, lymphocytes and myeloid cells) to the blood vessel wall. Over the last several decades extensive work has been conducted that details the many molecular pathways involved in mediating the pathologic vascular inf...
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BACKGROUND Kruppel-like factor 2 (KLF2) is an important zinc-finger transcription factor that maintains endothelial homeostasis by its anti-inflammatory, -thrombotic, -oxidative, and -proliferative effects in endothelial cells. In light of the potent vasoprotective effects of KLF2, modulating KLF2 expression or function could give rise to new therapeutic strategies to treat cardiovascular disea...
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Activation of cells intrinsic to the vessel wall is central to the initiation and progression of vascular inflammation. As the dominant cellular constituent of the vessel wall, vascular smooth muscle cells (VSMCs) and their functions are critical determinants of vascular disease. While factors that regulate VSMC proliferation and migration have been identified, the endogenous regulators of VSMC...
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Atherosclerosis is now understood to be a disease characterized by inflammation that results in a host of complications, including ischemia, acute coronary syndromes (unstable angina pectoris and myocardial infarction), and stroke. Inflammation may be caused by a response to oxidized low-density lipoproteins, chronic infection, or other factors; and markers of this process, such as C-reactive p...
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ژورنال
عنوان ژورنال: Current Atherosclerosis Reports
سال: 2012
ISSN: 1523-3804,1534-6242
DOI: 10.1007/s11883-012-0268-6